Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.

Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex.

Next-generation sequencing to generate interactome datasets.

Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.

A proteome-scale map of the human interactome network.

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.

Architecture of the human interactome defines protein communities and disease networks.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex.

PDK isozymes phosphorylate PDHC subunit E1

PDP1,2 dephosphorylate p-lipo-PDH

DLD dimer dehydrogenates dihydrolipoyl

DLAT trimer transfers acetyl to CoA

PDH E1 decarboxylates PYR, transferring acetyl to DLAT

UniProtKB entry O00330 (ODPX_HUMAN), Pyruvate dehydrogenase protein X component, mitochondrial