Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Prenylated prelamin A interacts with Narf, a novel nuclear protein.
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Human NARF constructs localize to nuclei and bind prenylated prelamin A; the paper does not establish activity of the selected 217-residue product.
"When a FLAG epitope-tagged Narf is expressed
in HeLa cells, it is exclusively nuclear and partially co-localizes with the
nuclear lamina."
A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis.
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Compared with IOP1 depletion, IOP2/NARF depletion did not impair cytosolic or mitochondrial aconitase activity, distinguishing the paralogs in this tested CIA phenotype.
"Knockdown of IOP2, in contrast, had no
effect on either."
Exact NARF product-to-reference sequence mapping
Frozen exact-input ProtNLM output and UniProt sequence for J3KS48