GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/bcsA/bcsA-uniprot.txt

UniProtKB entry for bcsA

UniProt identifies BcsA as the UDP-forming cellulose synthase catalytic subunit in bacterial cellulose biosynthesis.

file:PSEPK/bcsA/bcsA-goa.tsv

QuickGO GOA annotations for bcsA

file:interpro/panther/PTHR43867/PTHR43867-metadata.yaml

PANTHER family metadata for bcsA

PANTHER places BcsA in a glycosyltransferase 2/OpgH-family-related cellulose synthase subfamily.

PMID:23222542

Crystallographic snapshot of cellulose synthesis and membrane translocation.

The BcsA-B crystal structure establishes BcsA as the inner-membrane catalytic cellulose synthase subunit and BcsB as its membrane-anchored periplasmic partner.

"The inner membrane protein BcsA is the catalytically active subunit and contains a conserved family two GT-domain between TM-helices 4 and 5"

PMID:24704788

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP.

BcsA carries the PilZ-domain c-di-GMP switch that relieves autoinhibition of the cellulose synthase.

"BcsA forms a PilZ domain within its C-terminal intracellular extension"

file:PSEPK/bcsA/bcsA-deep-research-openscientist.md

OpenScientist gene research for bcsA

OpenScientist verifies Q88JL4/PP_2635 as the canonical GT2/PilZ BcsA cellulose synthase rather than an orphan pseudomonad BcsA-like cyclic-beta-glucan synthase.

"This is the *canonical* BcsA, distinct from the recently described "orphan" BcsA"