Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniPathway vocabulary mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
UniProt record for PSEPK PP_1451 (Q88MW7)
Characterization of Pseudomonas aeruginosa l,d-Transpeptidases and Evaluation of Their Role in Peptidoglycan Adaptation to Biofilm Growth.
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Pseudomonas LdtPae3 is tentatively assigned as a peptidoglycan-OprI tether hydrolase.
"The function of LdtPae3 was tentatively assigned to the release of OprI based on both the absence of detectable amide bond-forming activity (formation of 3→3 and tripeptide→ OprI bonds) and the close similarity between LdtPae3 and E. coli hydrolase YafK."
Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF.
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E. coli LdtF/YafK is a murein endopeptidase that cleaves Lpp from peptidoglycan.
"Here, using genetic and biochemical approaches, we show that LdtF (formerly yafK), a newly identified paralog of l,d-transpeptidases in E. coli, is a murein hydrolytic enzyme that catalyzes cleavage of Lpp from the PG sacculus."
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E. coli LdtF also has glycine-specific carboxypeptidase activity on terminal-glycine muropeptides.
"LdtF also exhibits glycine-specific carboxypeptidase activity on muropeptides containing a terminal glycine residue."
DpaA Detaches Braun's Lipoprotein from Peptidoglycan.
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E. coli DpaA/LdtF hydrolyzes the Lpp-peptidoglycan linkage.
"We now show that LdtF hydrolyzes the Lpp-peptidoglycan linkage, detaching Lpp from peptidoglycan, and have renamed LdtF to peptidoglycan meso-diaminopimelic acid protein amidase A (DpaA)."
PANTHER PAINT annotations for PTHR36699
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PAINT places endopeptidase and carboxypeptidase activities at a bacterial PTHR36699 ancestral node using P0AA99 as experimental descendant evidence.
"PTHR36699 PTN002195972 GO:0004175 F IBD false UniProtKB:P0AA99 taxon:2 20241031"
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PAINT separately places carboxypeptidase activity at the same bacterial ancestral node from P0AA99.
"PTHR36699 PTN002195972 GO:0004180 F IBD false UniProtKB:P0AA99 taxon:2 20241031"
OpenScientist PSEPK tether-remodeling pathway report