Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.

Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.

Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.

Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.

CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.

Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.

Toll-like receptor 8 senses degradation products of single-stranded RNA.

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Small-molecule inhibition of TLR8 through stabilization of its resting state.

TLR8 Is a Sensor of RNase T2 Degradation Products.

Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.

Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function.

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Full-length TLR3/7/8/9 binds to UNC93B1

UNC93B1 delivers endosomal full-length TLRs to endolysosome

Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex

Endosomal TLRs pass through the Golgi

TLR8 dimer binds TLR7, TLR8 ligands

TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA

Falcon deep research report on TLR8