UniProt record for human ARAF (P10398)
Falcon deep research report for human ARAF
Isoform-specific localization of A-RAF in mitochondria.
Raf family kinases: old dogs have learned new tricks.
BRAF activation by metabolic stress promotes glycolysis sensitizing NRAS(Q61)-mutated melanomas to targeted therapy.
Structural basis for SHOC2 modulation of RAS signalling.
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Identification of interaction between MEK2 and A-Raf-1.
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
A human MAP kinase interactome.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Toward an understanding of the protein interaction network of the human liver.
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Architecture of the human interactome defines protein communities and disease networks.
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.
HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress.
A central chaperone-like role for 14-3-3 proteins in human cells.
YWHAB dimer dissociates from dephosphorylated RAF
PP2A dephosphorylates inactive RAFs
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
PAQR3 binds inactive RAFs
Raf dimer inhibitors bind RAF heterodimers
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs