Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
The Polycomb group protein EZH2 directly controls DNA methylation.
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.
Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
A proteome-scale map of the human interactome network.
Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport.
Structural basis for DNMT3A-mediated de novo DNA methylation.
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PRC2 recruits DNA methyltransferases
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
DNMT3A binds Me2sR4-HIST1H4
The GSDME gene promoter is hypermethylated
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice.
The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.
DNA methyltransferase expression in the mouse germ line during periods of de novo methylation.
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis.
Cellular epigenetic modifications of neural stem cell differentiation.
DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes.
Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12).
Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression.
Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1.
Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading.
Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus.
Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart.
[Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats].
MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage.
Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter.
Cocaine represses protein phosphatase-1Cβ through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain.
Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes.
Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC).
Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats.
LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration.
SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes.