daf-4 (P50488) review notes
- Deep research: the first falcon run timed out at 600 s. A rerun with
--timeout 1500 produced daf-4-deep-research-falcon.md.
- The only type II receptor, shared by the DAF-7 (with DAF-1) and DBL-1 (with SMA-6) pathways PMID:9847239.
- Binds BMP-2/4 in COS cells PMID:8413626.
- Plasma membrane [PMID:24550286; PMID:21408209; PMID:9334330]. Recycles via ARF-6, independently of retromer PMID:24550286. Surface levels depend on TSP-12/TSP-14 PMID:31988138.
- A truncated isoform from alternative polyadenylation antagonizes signaling PMID:15254038. The negative-regulation row is kept as non-core and isoform-specific.
- Added NEW GO:0098821 BMP receptor activity (IC). IBA signaling receptor complex changed to BMP receptor complex.
- Two core functions: BMP receptor activity (Sma/Mab) and TGF-beta receptor activity (DAF-7, dauer).