Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine.
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ELT-2 is essential for intestinal development
"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine."
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elt-2 null mutants die at L1 larval stage with malformed gut cells
"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine."
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elt-2 is expressed gut-specifically from 2E cell stage through adulthood
"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine."
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Ectopic elt-2 expression causes ectopic ges-1 expression
"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine."
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ELT-2 likely autoregulates its own promoter
"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine."
Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo.
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ELT-2::GFP binds to elt-2 promoter in discrete nuclear foci in living embryos
"Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo."
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ELT-2 directly autoregulates its own promoter
"Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo."
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Demonstrates sequence-specific DNA binding in vivo
"Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo."
The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans.
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ELT-2 is a strong transcriptional activator in yeast assays
"The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans."
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ELT-2 binds specifically to WGATAR sequences in vitro
"The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans."
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ELT-4 is a duplicated but apparently non-functional paralog
"The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans."
Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine.
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pho-1 is a direct target of ELT-2
"Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine."
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ELT-2 binds to WGATAR site in pho-1 promoter in vitro
"Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine."
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Loss of ELT-2 destroys pho-1 reporter expression
"Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine."
Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
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ELT-2 regulates sphingosine-1-phosphate lyase (spl-1) expression
"Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors."
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ELT-2 binds GATA motif in spl-1 promoter
"Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors."
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ELT-2 can activate spl-1 promoter in yeast system
"Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors."
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.
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ELT-2 is major regulator of intestinal immune responses to P. aeruginosa
"A conserved role for a GATA transcription factor in regulating epithelial innate immune responses."
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Required for infection responses and survival on pathogen
"A conserved role for a GATA transcription factor in regulating epithelial innate immune responses."
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Function is conserved - human GATA6 has similar protective role
"A conserved role for a GATA transcription factor in regulating epithelial innate immune responses."
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ELT-2 does not contribute to resistance to cadmium, heat, or oxidative stress
"A conserved role for a GATA transcription factor in regulating epithelial innate immune responses."
Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans.
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ELT-2 mediates osmosensitive gene expression in intestine
"Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans."
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Works with ELT-3 (hypodermal) for organismal osmotic stress resistance
"Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans."
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GATA binding sites required for osmosensitive gene activation
"Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans."
Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan.
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ELT-2 regulates daf-16d/f isoform expression in intestine
"Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan."
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Required for daf-16 expression and lifespan extension
"Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan."
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ELT-2 and ELT-4 promote longevity via DAF-16a and DAF-16d/f
"Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan."
The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans.
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ELT-2 controls p38-dependent immune gene induction
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
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Cooperates with ATF-7 and SKN-1 downstream of p38
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
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Regulates constitutive digestive enzyme expression in adults
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
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Essential for both basal and induced immune gene expression
"The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans."
A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway.
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ELT-2 directly binds and activates 44bp vit-2 enhancer
"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway."
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Works with MAB-3, FKH-9, and DAF-16 to regulate vit-2
"A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-β/Sma/Mab pathway."
The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans.
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ELT-2 regulates prmt-1 expression transcriptionally
"The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans."
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ELT-2 physically interacts with PRMT-1 protein
"The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans."
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ELT-2 inhibits PRMT-1 methyltransferase activity through protein interaction
"The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans."
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
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Used elt-2::GFP as marker for intestinal cells
"Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx."
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Not a direct study of elt-2 function
"Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx."
Deep research report on elt-2