Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter.
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Co-expression of SLC7A9 with rBAT produces a functional system b(0,+)-like transporter complex.
"b(0,+)AT and rBAT in human retinal pigment epithelial cells"
rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.
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Human kidney brush-border rBAT and SLC7A9 occur as heterodimers.
"rBAT and b(0,+)AT were solely expressed as heterodimers of identical size"
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The heterodimer accounts for nearly all apical cystine reabsorption in proximal tubules.
"responsible for virtually all apical cystine reabsorption"
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Cryo-EM structure of the human heteromeric amino acid transporter b(0,+)AT-rBAT.
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rBAT is the heavy chain that traffics SLC7A9 to the membrane.
"a heavy chain which mediates the membrane trafficking of b0,+AT"
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The glycosidase-like extracellular domain has no detected alpha-glucosidase activity.
"The results showed that the complex has no α-glucosidase activity"
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rBAT supplies the oligomerization interface between heterodimers.
"rBAT mediates the dimerization of HATs"
Structural basis for amino acid exchange by a human heteromeric amino acid transporter.
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The light chain is the transport subunit and the heavy chain controls maturation and surface delivery.
"The light chain constitutes the transport subunit whereas the heavy chain mediates trafficking to the plasma membrane"
Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine.
Luminal heterodimeric amino acid transporter defective in cystinuria.
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SLC7A9, rather than rBAT, is the catalytic subunit of the complex.
"b(0,+)AT as the catalytic subunit that associates by a disulfide bond with rBAT"
The structural and functional units of heteromeric amino acid transporters. The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters.
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rBAT determines higher-order oligomerization of system b(0,+).
"The heavy subunit rBAT dictates oligomerization of the heteromeric amino acid transporters"
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One heavy-light heterodimer is sufficient as the functional unit.
"a single heterodimer is the functional unit"
Regional and subcellular distribution of a neutral and basic amino acid transporter in forebrain neurons containing nitric oxide synthase.
SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu
Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu
Manual SLC3A1 research synthesis
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Manual synthesis distinguishes rBAT accessory activity from SLC7A9 catalysis and records evidence boundaries.
"SLC3A1 is therefore a transporter-activating heavy chain and an essential complex component, not the amino-acid permeation pathway itself."