Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Deep research summary for Bacteriophage T4 adfA
-
AdfA (gp61.2) is a phage-encoded anti-defense protein that inhibits the host DarT DNA ADP-ribosyltransferase toxin and prevents ADP-ribosylation of viral DNA.
"**Primary functional role:** AdfA is a phage-encoded **anti-defense** factor that counteracts DarTG-mediated defense by **inhibiting DarT toxin activity**, preventing detectable ADP-ribosylation of phage DNA in the escape context, and thereby restoring productive infection."
-
Ectopic expression of evolved RB69 gp61.2(R164H) or the T4 homolog improves plating efficiency on DarTG1 hosts.
"Ectopic expression of evolved gp61.2(R164H) or a T4 homolog improved RB69 **efficiency of plating (EOP)** on DarTG1 hosts"
UniProtKB entry P39229 (ADFA_BPT4)
-
AdfA counteracts the host DarT anti-phage defense system and belongs to the Anti-DarT factor A family (PF23813).
"Plays a role in counteracting the host DarT defense system. {ECO:0000250|UniProtKB:Q7Y5A4}."