Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CDK5-cyclin B1 regulates mitotic fidelity.
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CDK5, long classified as an atypical CDK without a direct cell-cycle role, is active during mitosis and partners with cyclin B1 (not only its neuronal p35/p39 activators) to maintain mitotic fidelity, validating CDK5 cell-cycle-regulation annotations as a genuine extra-neuronal function.
"CDK5 is active throughout mitosis"
Falcon deep research report for CDK5
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Falcon deep research corroborates the existing CDK5 review (p35/p39 activation, p25 hyperactivation, tau/synaptic/cytoskeletal substrates, neurodegeneration) and surfaces the 2024 Nature CDK5-cyclin B1 mitotic-fidelity finding plus additional substrate-specific roles (Drp1 mitochondrial fission, CLOCK/PER2 circadian, PRMT1-mTORC1).
"CDK5 can form a complex with cyclin B1 and regulate mitotic fidelity, challenging the traditional view that CDK5 has no cell cycle function"
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner.
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein.
Mechanism of CDK5/p25 binding by CDK inhibitors.
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.
A family of human cdc2-related protein kinases.
cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells.
PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners.
Microtubule association of the neuronal p35 activator of Cdk5.
Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin.
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro.
Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor.
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.
Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control.
Cdk5: multitasking between physiological and pathological conditions.
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Review summarizing CDK5 as a proline-directed serine/threonine kinase linked to neuronal migration, cortical layering, synaptic plasticity, and neurodegenerative dysregulation.
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Adipocyte NCoR knockout decreases PPARĪ³ phosphorylation and enhances PPARĪ³ activity and insulin sensitivity.
Synaptic vesicle pools and dynamics.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The protein interaction landscape of the human CMGC kinase group.
CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration.
Memory enhancement by targeting Cdk5 regulation of NR2B.
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CDK5 phosphorylates NR2B/GluN2B Ser1116, regulating NMDAR surface expression, synaptic transmission, and memory.
A proteome-scale map of the human interactome network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Roles of tau protein in health and disease.
Architecture of the human interactome defines protein communities and disease networks.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Phosphorylated tau interactome in the human Alzheimer's disease brain.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Identification and functional characterization of transcriptional activators in human cells.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems.
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
CDK5 phosphorylates DARPP-32 on Thr75
Phosphorylation of CRMPs by Cdk5
Phosphorylation of CRMPs by GSK3beta
p25-bound CDK5 phosphorylates CDC25B
p25-bound CDK5 phosphorylates CDC25C
p25-bound CDK5 phosphorylates CDC25A
CDK5:p25 translocates to the nucleus
Ntrk2 phosohorylates CDK5
UniProtKB record for human CDK5
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UniProt summarizes CDK5 as a proline-directed serine/threonine kinase activated by CDK5R1/CDK5R2, with neuronal, synaptic, cytoskeletal, apoptosis, and substrate-specific autophagy functions.