Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.
Analysis of PALB2/FANCN-associated breast cancer families.
PALB2 is an integral component of the BRCA complex required for homologous recombination repair.
PALB2 regulates recombinational repair through chromatin association and oligomerization.
Structural basis for recruitment of BRCA2 by PALB2.
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
Structural basis for molecular interactions involving MRG domains: implications in chromatin biology.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.
Structural Basis for Multi-specificity of MRG Domains.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.
Architecture of the human interactome defines protein communities and disease networks.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction.
Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction.
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
Ligation of DNA and formation of Holliday structures following repair synthesis
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding