GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
PMID:19910644
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity.
PMID:21771332
Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.
PMID:17957153
Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations.
PMID:11460888
Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.
GO_REF:0000033
Annotation inferences using phylogenetic trees
PMID:27037668
Inhibition of Leptin-ObR Interaction Does not Prevent Leptin Translocation Across a Human Blood-Brain Barrier Model.
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
PMID:22405007
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32822567
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:9054940
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.
Reactome:R-HSA-1183003
Expression of Leptin
PMID:9537324
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
PMID:25060689
Leptin modulates autophagy in human CD4+CD25- conventional T cells.
PMID:8589726
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin.
PMID:19688109
Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production.
PMID:12504075
Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines.
PMID:36959263
Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
PMID:24340098
Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK.
PMID:17344214
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
PMID:28270795
The Leptin Receptor Complex: Heavier Than Expected?
PMID:15899045
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1.
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:27986616
Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice.
file:human/LEP/LEP-uniprot.txt
UniProtKB entry P41159 (LEP_HUMAN), Leptin
PMID:12393845
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
PMID:7624777
Weight-reducing effects of the plasma protein encoded by the obese gene.
PMID:9202122
Congenital leptin deficiency is associated with severe early-onset obesity in humans.
file:human/LEP/LEP-deep-research-falcon.md
Falcon deep research report for human LEP