Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
NAK is an IkappaB kinase-activating kinase.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.
Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses.
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.
Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.
Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization.
Expanding the substantial interactome of NEMO using protein microarrays.
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection.
Network organization of the human autophagy system.
Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Emerging roles for the non-canonical IKKs in cancer.
Novel cross-talk within the IKK family controls innate immunity.
TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.
Functional dissection of the TBK1 molecular network.
Toward an understanding of the protein interaction network of the human liver.
Activation of STAT6 by STING is critical for antiviral innate immunity.
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Activation of interferon regulatory factor 5 by site specific phosphorylation.
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex.
MAVS protein is attenuated by rotavirus nonstructural protein 1.
Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response.
RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
The TBK1-binding domain of optineurin promotes type I interferon responses.
Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3.
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.
Architecture of the human interactome defines protein communities and disease networks.
TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.
TRIM23 mediates virus-induced autophagy via activation of TBK1.
The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation.
Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity.
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877.
Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.
TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease.
Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production.
E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Evasion of Type I Interferon by SARS-CoV-2.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.
SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1.
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
MicroRNA-4691-3p inhibits the inflammatory response by targeting STING in human dental pulp cells: A laboratory investigation.
Multimodal cell maps as a foundation for structural and functional genomics.
Phosphorylation and release of IRF3
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
STING recruits TBK1 and IRF3
STING mediated induction of host immune responses
TBK1 is phosphorylated within STING:TBK1:IRF3 complex
IRF3 is phosphorylated by TBK1
TBK1 phosphorylates STAT6 at Ser407
STING recruits TBK1 and STAT6
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
TBK1 is phosphorylated within STING:TBK1:STAT6 complex
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
IRF3-mediated induction of type I IFN
PINK1-PRKN Mediated Mitophagy
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
Phosphorylation and release of IRF3/IRF7
Phosphorylation and release of IRF7
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
Recruitment of IRF7 to TRAF6
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
SARS-CoV-2 nsp6 binds TBK1
SARS-CoV-2 nsp13 binds TBK1
TBK1 or IKBKE forms homodimers
TBK1, IKBKE form homodimers
TBK1, IKBKE are autophosphorylated at Ser172
Phosphorylation of TBK1/IKBKE
HSP90 binds TBK1 and IRF3
MAVS:TOMM70 recruits HSP90:TBK1:IRF3
SARS-CoV-1 M protein interacts with TBK1/IKBKE
TBK1, IKBKE phosphorylate RIPK1 at T189
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
TBK1 is phosphorylated within the activated TLR4 complex
Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
OPTN binds TBK1 within the activated TLR4 complex
OPTN, TBK1 bind ubiquitinated MOM proteins
MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria
TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
p-S-TBK1 phosphorylates OPTN
TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3
TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
TBK1 is phosphorylated within the activated TLR3 complex
OPTN binds TBK1 within the activated TLR3 complex