Vwf (mouse) review notes

Session 1

Fetched Q8CIZ8 (Swiss-Prot VWF_MOUSE, MGI:98941, GeneID 22371); 69 GOA rows.
Literature summarized in Vwf-deep-research-manual.md (no deep-research provider).
Human VWF review (genes/human/VWF) used for consistency of ISO/ISS judgments; the
mouse ISO/ISS rows all descend from human P04275 or rat RGD:621759.

Core: collagen binding, GPIb (cell adhesion molecule) binding, integrin binding,
FVIII carrier, self-association; processes hemostasis, cell-substrate adhesion,
blood coagulation; locations extracellular region/matrix and Weibel-Palade body.
Liver/placenta development (PMID:7854452): the paper is the Hgf knockout and the
With/From allele is Hgf (MGI:1857656). Wrong gene product upstream. The
cached copy is abstract-only, so per the session rules the rows are UNDECIDED with a
WRONG_GENE_PRODUCT source defect rather than REMOVE. PMID:7854452
External side of plasma membrane (PMID:8562500): CD24/P-selectin paper; abstract does
not mention VWF. UNDECIDED with a SUSPECTED wrong-gene defect (CHECK).
Immunoglobulin binding rows: derived from human PMID:3121636, where the partner is
BiP ("heavy chain binding protein"), an ER chaperone. MODIFY to protein-folding
chaperone binding; source defect on the human UniProt row.
Platelet activation: positive rows (ligand role for GPIb signalling) non-core; the NOT
row (PMID:17380206, laser injury, thrombin-driven) is context-specific; consistency
exception recorded.
ECM structural constituent: over-annotation (VWF is an adhesive bridge, not
load-bearing matrix), consistent with human review.
PMID:20097747 is a rat study using anti-vWF only as an endothelial marker; not
informative for Vwf function (LOW relevance).

VWF is the structural driver of Weibel-Palade body formation PMID:11274431. GO:0033363 secretory granule organization could fit (VWF tubules are the
organelle's scaffold), but this was left as a suggested question rather than a NEW
row, pending a comparator check of how GO treats cargo-scaffold proteins.