Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis.
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Dd-STATa is the transcriptional repressor that binds stalk-cell gene repressor elements and regulates commitment to stalk-cell differentiation.
"Dd-STATa is the repressor protein that regulates commitment"
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Loss of Dd-STATa leads to over-induction of the stalk-cell gene ecmB by DIF, confirming its repressor role.
"is greatly overinduced by DIF in Dd-STATa null cells."
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Dd-STATa null slugs arrest and fail to culminate normally.
"Dd-STATa null slugs remain developmentally arrested for several days"
Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein.
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Dd-STATa is present in the nuclei of growing and developing cells, with regulated nuclear enrichment.
"All growing and developing Dictyostelium cells appear to contain a small amount of Dd-STATa in their nuclei"
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GskA (GSK-3) phosphorylation enhances nuclear export of Dd-STATa, providing biphasic control of its nuclear residence.
"Phosphorylation by GskA enhances nuclear export of"
The Dictyostelium prestalk cell inducer DIF regulates nuclear accumulation of a STAT protein by controlling its rate of export from the nucleus.
Structure of an activated Dictyostelium STAT in its DNA-unbound form.
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The tyrosine-phosphorylated Dd-STATa homodimer has a four-domain STAT architecture similar to mammalian STAT1/STAT3.
"Dd-STATa is a STAT protein which transcriptionally regulates cellular"
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Dd-STATa homodimerizes through SH2 domain:phosphopeptide and direct SH2-SH2 interactions.
"Dimerization is mediated by SH2 domain:phosphopeptide"
Identification of new modes of Dd-STATa regulation of gene expression in Dictyostelium by in situ hybridisation.
Evidence that the Dictyostelium STAT protein Dd-STATa plays a role in the differentiation of inner basal disc cells and identification of a promoter element essential for expression in these cells.
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Dd-STATa is required in the slug for correct entry into culmination and for differentiation of pstAB core cells.
"is necessary in the slug for correct"
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The aslA::lacZ reporter, a Dd-STATa target, is not expressed in null slugs.
"the aslA::lacZ fusion gene is not expressed in Dd-STATa-null slugs."
High-throughput analysis of spatio-temporal dynamics in Dictyostelium.
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A dstA (STATa) insertion mutant is developmentally defective from the slug stage onward in a high-throughput phenotype screen.
"carrying an insertion in dstA, a gene encoding the STATa transcription factor, which under our assay conditions was defective only from the slug stage on"
Regulation of ecmF gene expression and genetic hierarchy among STATa, CudA, and MybC on several prestalk A-specific gene expressions in Dictyostelium.
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STATa is important for tip organizer function in the migrating slug.
"important for the organizer function in the tip region of the"
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STATa positively regulates mybC and indirectly upregulates ecmF in a CudA-independent manner.
"whose expression is positively regulated by STATa."
Analysis of DrkA kinase's role in STATa activation.
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STATa is activated by tyrosine phosphorylation on Tyr702 in response to extracellular cAMP.
"STATa is activated by phosphorylation on Tyr702 when cells are exposed to"
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The receptor-like kinase DrkA phosphorylates STATa on Tyr702 in an SH2-dependent manner.
"phosphorylate STATa on Tyr702 in a STATa-SH2 (phosphotyrosine binding)"
SH2 signaling in a lower eukaryote: a STAT protein that regulates stalk cell differentiation in dictyostelium.
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The DIF-activated TTGA-binding factor that regulates stalk-cell differentiation is a STAT protein.
"The TTGA-binding factor is a transcriptional regulator activated by DIF"
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Dd-STATa binds specifically to a mammalian interferon-stimulated response element, demonstrating sequence-specific DNA binding.
"it will bind specifically to a mammalian"
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Dd-STATa functions via reciprocal phosphotyrosine-SH2 interactions like metazoan STATs.
"a phosphotyrosine residue on one molecule with an SH2 domain on a dimerizing"
Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.
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Dd-STATa tyrosine phosphorylation and nuclear translocation are induced by extracellular cAMP through the serpentine receptor cAR1.
"The tyrosine phosphorylation and nuclear localization of Dd-STAT are induced very rapidly by extracellular cAMP through the serpentine cAMP receptor cAR1"
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Activated Dd-STAT translocates into nuclei; nuclear enrichment is maintained in tip-forming prestalk cells.
"translocates into the nuclei of all cells"
OpenScientist assessment of STATa proliferation regulation and defense response
Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.
Immune-like phagocyte activity in the social amoeba.
PTHR11801 PAINT ancestral annotations