CC2D2A: human–horse sequence comparison

The downloaded human Q9P2K1 sequence (1620 residues) and selected horse A0A5F5PJ44 sequence (1480 residues) share 90.3% identity among 1478 paired residues. Paired coverage is 91.2% of human and 99.9% of horse.

Full alignments, sequence hashes and calculation details: CC2D2A.json. Reproduce with compare.py using the two downloaded UniProt text records. See the methods and limitations.

• [x] Computed from sequence inputs; no hardcoded results.
• [x] The same script was run on ten different gene pairs.
• [x] Alignment completed and full output retained.
• [ ] Orthology, gene-model completeness and conservation of each biological claim require additional evidence. Sequence similarity alone does not establish them.

Current UniProt sequences were compared; their identity with the original ProtNLM input sequences has not been established.

Domain context

The horse sequence lacks aligned human residues 1–49 and 147–239. Both intervals fall within the human UniProt record's predicted disordered region 1–241. The long coiled-coil and C2-domain-containing architecture is retained. These gaps therefore do not by themselves demonstrate loss of the conserved ciliary scaffold. This is a domain-context inference, not experimental confirmation of the horse model.