Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.
-
mexJK expression is negatively regulated by the TetR-family MexL; a mexL HTH mutation gives triclosan resistance.
"Expression of this operon is negatively regulated by the product of mexL, a gene located upstream of and transcribed divergently from mexJK"
Molecular characterization of MexL, the transcriptional repressor of the mexJK multidrug efflux operon in Pseudomonas aeruginosa.
-
Purified MexL is a tetramer and binds the mexL-mexJ intergenic region (EMSA, footprinting).
"Gel mobility shift and footprinting assays demonstrated that MexL, but not MexL(A47D), binds specifically to the 94-bp mexL-mexJ intergenic region"
PA3678 (PA3678) review notes