piwi review notes

• Deep research: SKIPPED (falcon times out in this environment; perplexity-lite not installed). No deep-research file was generated or fabricated.
• Evidence sources: cached publications (just fetch-gene-pmids DROME piwi), the UniProt record (piwi-uniprot.txt), and additional mouse/fly
  primary papers fetched with just fetch-pmid (e.g. PMID:18922463, PMID:22020280, PMID:29437694, PMID:20011505, PMID:22902557).
• Reviewed as an exemplar for a generalized animal piRNA silencing module.

Key points

• Nuclear co-transcriptional TE silencer; slicer dispensable PMID:22902557.
• 14 generic protein-binding IPIs removed as uninformative (partners Papi, Vret, Panx, Nxf2, Nup358 etc.).
• Chromatin DNA binding (DamID) marked over-annotated: the paper itself notes RNA- not DNA-mediated chromatin contact.