Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Identification of a malate chemoreceptor in Pseudomonas aeruginosa by screening for chemotaxis defects in an energy taxis-deficient mutant.
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PA2652 is the malate chemoreceptor, identified by its chemotaxis defect in an aer background.
"We identified PA2652 as a chemoreceptor for malate by screening aer mcp double mutants by using swarm plate assays."
The activity of the C4-dicarboxylic acid chemoreceptor of Pseudomonas aeruginosa is controlled by chemoattractants and antagonists.
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The CtpM (PA2652) ligand binding domain binds five C4-dicarboxylic acids; three are attractants, two antagonists; signalling goes through the che pathway.
"the ligand binding domain (LBD) of the chemoreceptor PA2652 directly recognizes five C4-dicarboxylic acids"