Curation Notes: ureA (C5CXZ7, Vapar_4240) in Variovorax paradoxus S110 (VARPS)

Summary

• Gene / Locus: ureA (Vapar_4240, UniProtKB C5CXZ7, Swiss-Prot reviewed, 100 aa).
• Genomic Context: Encoded on Chromosome 1 (CP001635, Han et al. 2011, PMID:21183664(https://pubmed.ncbi.nlm.nih.gov/21183664/)) at the head of the ure gene cluster (Vapar_4240 ureA, Vapar_4242 ureB, Vapar_4243 ureC, Vapar_4248 ureG).
• Subunit Role: Gamma structural subunit (HAMAP MF_00739, InterPro:IPR012010, Pfam:PF00547) of the $(\text{UreABC})_3$ trimer of heterotrimers (PMID:8718850(https://pubmed.ncbi.nlm.nih.gov/8718850/)). Because the carbamylated dinickel catalytic center is housed exclusively within the $(\alpha\beta)_8$ TIM-barrel of the alpha subunit UreC (Vapar_4243, C5CY00), GO:0016151 (nickel cation binding) is REMOVEd and enables GO:0009039 (urease activity) is marked MARK_AS_OVER_ANNOTATED, while GO:0005198 (structural molecule activity), GO:0035550 (urease complex), and contributes_to GO:0009039 capture the subunit's structural role in MODULE:urease_biogenesis_urea_hydrolysis.