vgrG1c (PA2685, Q9I0F3) notes

Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)

Fetched with just fetch-gene PSEAE Q9I0F3 --alias vgrG1c; accession matches the
worklist (reviewed entry VGR1C_PSEAE). No deep-research provider key was
available. Same literature as vgrG1a; PMID:20114026 and PMID:21325275 read in
full.

Identity and literature

726 aa VgrG-family spike protein. Its gene is unlinked from HSI-I
PMID:20114026,
but is co-regulated with it through RetS. Originally named vgrG4.
Among the most abundant proteins of the on-state H1-T6SS secretome, and
required with vgrG1a for Hcp1 export
PMID:20114026.
ClpV1-dependent secretion and multimerisation
PMID:21325275;
redundancy with VgrG1a
PMID:21325275.
Carries a specific cargo, the Rhs protein RhsP1/Tse5
PMID:24794869.

PseudoCAP IBA-seed assessment

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN002088178	GO:0033103 protein secretion by the type VI secretion system	3 (Q9I0F3, Q9I737, Q9I741)	13 (3 taxa)	GO:0033103, IDA PMID:20114026 and IMP PMID:21325275 (PseudoCAP)	SOUND	Exported by the H1-T6SS and required, with VgrG1a, for Hcp1 export; both papers read in full.	vgrG1a (Q9I741), equally sound; vgrG1b (Q9I737), WRONG reference (genes/PSEAE/vgrG1b)	Yes
PTN002088178	GO:0033104 type VI protein secretion system complex	3 (Q9I0F3, Q9I737, Q9I741)	13 (3 taxa)	GO:0033104, IDA PMID:20114026 and IMP PMID:21325275 (PseudoCAP)	SOUND	Multimerises as a tail spike and behaves as an apparatus component, not cargo.	as above	Yes

Clade and node-term judgement as recorded in genes/PSEAE/vgrG1a: a tight
13-leaf VgrG clade in three taxa, so no GO_CENTRAL defect is warranted.

Decisions summary

ACCEPT: GO:0033103 (IBA, IDA, IEA, IMP), GO:0033104 (IBA, IDA, IEA, IMP).
KEEP_AS_NON_CORE: extracellular region (EXP, IEA).
Counts: ACCEPT 8, KEEP_AS_NON_CORE 2.
Defects: none for this gene (PSEUDOCAP 0, GO_CENTRAL 0).