Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.
Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity.
Regulation of acidification and apoptosis by SHP-1 and Bcl-2.
Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.
PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta.
Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells.
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Molecular cloning and characterization of SPAP1, an inhibitory receptor.
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.
Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor.
Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.
Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2.
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.
Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells.
Monitoring phosphatase reactions of multiple phosphorylated substrates by reversed-phase HPLC.
Identification of CLEC12B, an inhibitory receptor on myeloid cells.
ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2.
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*.
Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70.
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation.
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
FCRL6 receptor: expression and associated proteins.
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs.
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling.
Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells.
Induction of myelodysplasia by myeloid-derived suppressor cells.
Fine specificity and molecular competition in SLAM family receptor signalling.
A proteome-scale map of the human interactome network.
A THEMIS:SHP1 complex promotes T-cell survival.
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
Identification of CD112R as a novel checkpoint for human T cells.
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
The E3 ligases Itch and WWP2 cooperate to limit T(H)2 differentiation by enhancing signaling through the TCR.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release.
HIV-1 Vif suppresses antiviral immunity by targeting STING.
Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma.
Signaling via a CD27-TRAF2-SHP-1 axis during naive TÂ cell activation promotes memory-associated gene regulatory networks.
Cyclophosphamide, vincristine, and the blood testis barrier.
Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains.
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.
Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.
Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.
Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) dephosphorylation. Implications for the role of SHP-1 in the IL-4-induced signals in human B cells.
A novel phosphotyrosine motif with a critical amino acid at position -2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1.
A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5.
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.
The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.
Interaction of SHP1 and KIT
Interaction of PECAM-1 and SHP-1
Regulation of T cell activation by CD28 family
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
Interaction of SHP-1 or SHP-2 with phospho PD-1
SHP-1 and SHP-2 bind pBTLA
Interleukin-3, Interleukin-5 and GM-CSF signaling
Exocytosis of tertiary granule lumen proteins
Exocytosis of specific granule lumen proteins
PTPNs gene transcription and translation
SHP1 and SHP2 bind the common beta chain
Regulation of IFNA/IFNB signaling
The SHC1:SHIP1 complex is stabilized by GRB2
SHP1 and SHP2 dephosphorylate Y628 of IL3RB
PTPN6 dephosphorylates JAK3
DNMT1-dependent PTPN6 gene silencing
Dephosphorylation of JAK1 by SHP1
Falcon deep research synthesis for PTPN6