Creatine kinase U-type, mitochondrial (human)
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CKMT1A is a peripheral mitochondrial inner-membrane protein on the intermembrane side, consistent with the active octamer facing the mitochondrial intermembrane space.
"Mitochondrion inner membrane; Peripheral membrane"
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.
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Isolated the human mitochondrial creatine kinase gene and cDNA (the ubiquitous CKMT1 locus); the gene contains 9 exons encoding a 416-residue protein including a 38-residue mitochondrial transit peptide, and the data support the phosphocreatine shuttle hypothesis.
"support the phosphocreatine shuttle hypothesis"
Crystal structure of human ubiquitous mitochondrial creatine kinase.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Multimodal cell maps as a foundation for structural and functional genomics.
CKMT1 regulates the mitochondrial permeability transition pore in a process that provides evidence for alternative forms of the complex.
creatine + ATP => phosphocreatine + ADP [CK octamer]