Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of a human mitotic checkpoint gene: hsMAD2.
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1.
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint.
p31comet blocks Mad2 activation through structural mimicry
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint.
Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
Spindle checkpoint protein dynamics at kinetochores in living cells.
Towards a proteome-scale map of the human protein-protein interaction network
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.
A protein domain-based interactome network for C. elegans early embryogenesis
The influence of catalysis on Mad2 activation dynamics
Defining the human deubiquitinating enzyme interaction landscape
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint.
Systematic analysis of human protein complexes identifies chromosome segregation proteins
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage.
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.
Shugoshin is a Mad1/Cdc20-like interactor of Mad2
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
Toward an understanding of the protein interaction network of the human liver
Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor.
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
A proteome-scale map of the human interactome network
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Maximizing binary interactome mapping with a minimal number of assays
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Physical and functional interactome atlas of human receptor tyrosine kinases
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Therapeutic role of 2-stearoxyphenethyl phosphocholine targeting microtubule dynamics and Wnt/β-catenin/EMT signaling in human colorectal cancer cells.
Multimodal cell maps as a foundation for structural and functional genomics
Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation.
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
Evolution and function of the mitotic checkpoint
Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer.
Disruption of FAT10-MAD2 binding inhibits tumor progression
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.
MTBP plays a crucial role in mitotic progression and chromosome segregation
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression.
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions
MAD1 binding to kinetochore
MAD2 conversion to inhibitory state
MAD2 association with MAD1 kinetochore complex
Release of activated MAD2 from kinetochores
PLK1 phosphorylation of cohesin at centromeres
PP2A-B56 dephosphorylation of centromeric cohesin
ESPL1 (Separase) cleavage of centromeric cohesin
Separation of sister chromatids
CDK1 phosphorylation of CDCA5 (Sororin) at centromeres
Kinetochore capture of astral microtubules
CDC42:GTP recruiting DIAPH2-2 to kinetochores
AURKB phosphorylation of DIAPH2-2 at kinetochores
Kinetochore capture regulation by CDC42:GTP:p-DIAPH2-2
EML4 recruiting NUDC to mitotic spindle
MCC complex binding to APC/C complex
APC/C inactivation via CDC20 sequestration
Ubiquitination of Cyclin A by APC/C:Cdc20
Cyclin A association with APC/C
APC/C:Cdc20 activation by MCC dissociation
Multiubiquitinated Cyclin A degradation
Nek2A association with MCC:APC/C
Nek2A multiubiquitination
Deep research report on MAD2L1