GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
GO reference used by source annotation pipeline
Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain
D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man
Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes
Rat d-aspartate oxidase is more similar to the human enzyme than the mouse enzyme
Biochemical characterization of d-aspartate oxidase from Caenorhabditis elegans: its potential use in the determination of free d-glutamate in biological samples
Falcon (Edison Scientific) deep research report: rat Ddo (D3ZDM7), D-aspartate oxidase (EC 1.4.3.1)
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"**Ddo/DDO (D-aspartate oxidase; EC 1.4.3.1)** is an **FAD-containing flavoprotein** that catalyzes **oxidative deamination** of acidic D-amino acids to yield the corresponding **2-oxo acid**, **hydrogen peroxide (H2O2)**, and **ammonia (NH3)**"
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"In the case of **D-Asp**, the 2-oxo acid product is **oxaloacetate**"
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"DDO is **highly selective for acidic D-amino acids**, classically **D-Asp** and **D-glutamate (D-Glu)**"
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"the NMDA analog **N-methyl-D-aspartate (NMDA)** can be an efficient substrate; other D-amino acids are weak substrates"
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"Ddo is not a broad-spectrum D-amino acid oxidase (DAO-like), but rather a specialized enzyme controlling the pool of **acidic D-amino acids**"
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"DDO is an **FAD-dependent flavoenzyme**, and experimental recombinant preparations and assays include FAD, consistent with tight cofactor dependence"
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"peroxisomal localization positions DDO as a source of **peroxisomal H2O2**, linking Ddo activity not only to D-Asp turnover but also potentially to redox signaling/oxidative stress microdomains, depending on tissue context"
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"**Rat DASPO/DDO:** Km **2.3 mM**, kcat **31.1 s−1**, kcat/Km **14.1 s−1·mM−1**, specific activity **71.7 U/mg**"
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"D-Asp can stimulate **NMDA receptors** by binding the L-glutamate site, and DDO therefore indirectly modulates glutamatergic neurotransmission through D-Asp availability"
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"Ddo knockout is associated with **~10–20× higher brain D-Asp** in multiple regions, demonstrating that DDO-mediated catabolism strongly limits steady-state D-Asp"
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"rat Ddo likely contributes to endocrine regulation by limiting D-Asp in these tissues"