CHO1 (YER026C, P08456) notes

Activity

• PS synthase (EC 2.7.8.8) purified from microsomes PMID:6088519
• cho1 mutants make no PS; require Etn/Cho PMID:6988386
• Disruption abolishes PSS activity PMID:3031455

Location

• Microsomes/ER [UniProt:P08456]; activity also in OMM fractions PMID:3005242 - likely MAM.

Autophagy

• cho1 deletion blocks autophagosome formation PMID:41176028; but increases microlipophagy in presence of Etn PMID:41176028. Direction of the GOA "positive effect" on regulation of microlipophagy unclear -> UNDECIDED.

Curation observations

• Cytosol RCA rows -> MODIFY to ER membrane. PE biosynthesis rows kept non-core (Cho1 makes the PS precursor; Psd1/2 make PE).