Ass (CG1315, O97069) notes

Module: dmel_arginine_metabolism (with Arg, Argl).

Literature journal

• UniProt (by similarity to human ASS1): citrulline + aspartate + ATP -> argininosuccinate + AMP + PPi; homotetramer; cytosol.
• No urea cycle in insects: PMID:40081835; ASS/ASL retained in some insects to recycle NOS citrulline PMID:40081835.
• Insect arginase not an ammonia-detox enzyme PMID:10878001
• Deep research: falcon timed out on first attempt (see report); review based on UniProt and comparative genomics.

Decisions

• urea cycle IEA: REMOVE (consistent with Arg).
• everything else ACCEPT.