SGD gene description for MRE11 (yeast)
Evidence that protein length expansion and contraction is partly due to mutational events in premeiotic cells.
-
Ser/Thr-rich repeat regions in yeast ORFs correlate with Mre11 locations in premeiotic cells.
"we show that Ser/Thr-rich repeat regions are more generally associated with the location of Mre11p in premeiotic cells"
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio.
The proteome of Saccharomyces cerevisiae mitochondria.
Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism.
Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.
Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae.
Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae.
Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Mre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.
Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.
Mre11 mediates gene regulation in yeast spore development.
The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity.
A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair.
Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.
The Rad50 coiled-coil domain is indispensable for Mre11 complex functions.
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1.
Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae.
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.
Proteome-wide protein interaction measurements of bacterial proteins of unknown function.
DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.
Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.
Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks.
The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.
Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex.
Eukaryotic Rad50 functions as a rod-shaped dimer.
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.
The social and structural architecture of the yeast protein interactome.
Functions of the yeast meiotic recombination genes, MRE11 and MRE2.
Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.
Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae.
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.
Complex formation and functional versatility of Mre11 of budding yeast in recombination.
The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance.
Removal of SPO11 and Resection of 5' Ends of DNA (yeast)
Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.
Mre11-Rad50 oligomerization promotes DNA double-strand break repair.
UniProt entry P32829 (MRE11_YEAST)