ced-7 notes

Deep research status (2026-10-05)

No provider deep-research file exists for this gene. Providers were unavailable in this environment (see the ced-1 and ced-6 notes). The synthesis below was made by hand from cached publications, with inline quotes.

Identity

• UniProtKB:P34358, ABCA-family ABC transporter, the orthologue of ABCA1 PMID:17205124.
• PANTHER PTHR19229:SF271 (ABC TRANSPORTER CED-7). UniProt and PANTHER's own classification agree.
• Plasma membrane, broad embryonic expression PMID:9635425.

Function

• Acts in both cells PMID:9635425.
• Needed for CED-1 clustering PMID:11163239.
• Needed for actin reorganization PMID:15744306.
• PS efflux and vesicles PMID:22727702.
• Phagocyte PS exposure PMID:22727702.
• The transported substrate has not been established biochemically.

Over-annotation patterns (same as ced-1, ced-6)

• Wnt-paper IGIs (spindle, left/right, DTC) are marked over-annotated.
• The CED-8 and CSP-1 papers use ced-7 as a clearance-defective background PMID:23505386.
• GO:0005319 lipid carrier activity (IBA, PTN000442469): the bind-and-deliver definition fits soluble lipid-transfer proteins, not ABC transporters. It is marked over-annotated with a TERM_SCOPING_PROBLEM propagation review; node placement is not disputed.

Round 6 of projects/INVOLVED_IN_PRECOMPOSITION.md (2026-11-10): the two GO:1902742 MODIFY replacements and the three GOA GO:1904747 rows (previously KEEP_AS_NON_CORE, now MODIFY) now use GO:0043065 positive regulation of apoptotic process instead of the precomposed GO:1904747 positive regulation of apoptotic process involved in development, with decomposed_into.context_dropped. The sign correction (the gene promotes death from the engulfing cell rather than taking part in the dying cell's program) is unchanged; only the developmental context is dropped. Earlier mentions of GO:1904747 above are superseded.