Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.

Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2).

Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I

ND4, ND5 bind the 550kDa complex to form the 815kDa complex

Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.

From the 'black box' to 'domino effect' mechanism: what have we learned from the structures of respiratory complex I.