Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
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Reducing S6 kinase levels extends lifespan.
"reducing the levels of ribosomal proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans"
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
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rsks-1 lifespan extension depends on pha-4, and rsks-1 mutations suppress pha-4 larval lethality.
"rsks-1/S6 kinase mutations, but not ife-2/eIF4E, can suppress pha-4-associated larval lethality"
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
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Adult rsks-1 RNAi reduces autophagy.
"autophagy was reduced by knockdown of the S6 kinase RSKS-1, which increases translation downstream of TORC1 but also promotes autophagy"
S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.
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rsks-1 is used as a canonical TORC1 output; its RNAi reverses the nprl-3 rescue of elo-5 L1 arrest like raga-1/rheb-1 RNAi.
"We found that elo-5(−) nprl-3(ku540) animals treated with ife-2(RNAi) or rsks-1(RNAi), with or without C17ISO supplement, yielded results similar to those obtained with raga-1(RNAi) and rheb-1(RNAi) (Table 1)"
S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.
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RSKS-1 acts downstream of TOR/RAPTOR in the germline; T404 is required.
"rsks-1 (S6K) acts downstream of let-363 (TOR) and daf -15 (RAPTOR) for proper larval expansion of the germline progenitor pool"
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Germline-autonomous role in progenitor accumulation.
"rsks-1 (S6K) is required germline-autonomously for larval accumulation of germline progenitors, promoting both cell cycle progression and the proliferative fate"
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
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rsks-1 inhibition extends lifespan, slows development and reduces fecundity.
"Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to starvation"
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.
UniProt entry Q9NAH6 (KS6B_CAEEL)
Manual literature research for rsks-1