Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor.
Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase.
14-3-3zeta is an effector of tau protein phosphorylation.
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo.
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
Differential localization of HDAC4 orchestrates muscle differentiation.
The growth-promoting activity of the Bad protein in chicken embryo fibroblasts requires binding to protein 14-3-3.
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
14-3-3 inhibits Bad-induced cell death through interaction with serine-136.
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport.
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells.
Identification and characterization of the interaction between tuberin and 14-3-3zeta.
MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1.
14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo.
14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.
The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.
Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins.
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity.
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.
Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.
YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Identification of 14-3-3zeta as an EGF receptor interacting protein.
Raf-1 activation disrupts its binding to keratins during cell stress.
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.
14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding.
Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking.
14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on Ser9.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.
Modulation of 14-3-3 interaction with phosphorylated histone H3 by combinatorial modification patterns.
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.
The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins.
Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Effect of phosphorylation on interaction of human tau protein with 14-3-3zeta.
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta.
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1.
Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function.
14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent.
Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.
Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors.
Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.
Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin.
CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.
Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
A human MAP kinase interactome.
Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.
Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway.
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.
Bimodal regulation of FoxO3 by AKT and 14-3-3.
Proteomic characterization of the human sperm nucleus.
Toward an understanding of the protein interaction network of the human liver.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.
ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
A Y2H-seq approach defines the human protein methyltransferase interactome.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.
The functional interactome landscape of the human histone deacetylase family.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.
The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Quantitative interaction proteomics of neurodegenerative disease proteins.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.
Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Architecture of the human interactome defines protein communities and disease networks.
Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction.
Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization.
Structural characterization of 14-3-3ζ in complex with the human Son of sevenless homolog 1 (SOS1).
A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.
Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Differential Subcellular Distribution and Translocation of Seven 14-3-3 Isoforms in Response to EGF and During the Cell Cycle.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
A central chaperone-like role for 14-3-3 proteins in human cells.
Interactome dynamics of RAF1-BRAF kinase monomers and dimers.
Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
Systematic identification of post-transcriptional regulatory modules.
Multimodal cell maps as a foundation for structural and functional genomics.
Activation of Raf-1 by 14-3-3 proteins.
Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.
Sequestration of BAD protein by 14-3-3
Activation of BAD by calcineurin
XPO1 binds the beta-catenin:CBY complex
YWHAZ and XPO1 mediate the nuclear export of beta-catenin
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress
GP1b-IX-V binds 14-3-3-zeta
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
p-S193-KSRP binds 14-3-3zeta in the nucleus
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
Association of p-S216-CDC25C with 14-3-3 proteins
p-S585-IL3RB binds 14-3-3 proteins
14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2
14-3-3 zeta binding allows recruitment of PI3K
14-3-3 proteins bind AKT-phosphorylated FOXO1
14-3-3 proteins bind AKT-phosphorylated FOXO3
14-3-3 proteins bind AKT-phosphorylated FOXO4
SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins
SARS-CoV-2 N binds to 14-3-3 proteins