Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:23354437

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.

DRC1 loss disrupts N-DRC integrity and ciliary beating in human respiratory cells; algal mutants additionally reveal selective inner-arm and associated-complex defects.

PMID:34169321

Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse.

DRC1 loss causes severe sperm-flagellum abnormalities and infertility, with later disorganization of initially formed mouse spermatid axonemes.
Tagged co-immunoprecipitation detects DRC1 association with DRC2, DRC3, DRC4 and DRC5 under the reported expression conditions.

PMID:37258679

Axonemal structures reveal mechanoregulatory and disease mechanisms.

The human respiratory-axoneme structural inventory includes DRC1 and its N-DRC partners. Detailed algal scaffold architecture informs the homologous human placement without settling every human dynein-docking dependency.

PMID:20876659

CMF70 is a subunit of the dynein regulatory complex.

Trypanosome CMF70 associates with the dynein regulatory complex and is required for normal flagellar propulsion.

PMID:27914912

Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.

The accessible abstract reports a mouse FOXJ1-dependent ciliogenesis study; it does not expose the Drc1 cytosol experiment associated with the donor annotation.