slc7a10b notes

Setup and provenance

• Fetched with just fetch-gene on E7FE11 (TrEMBL, 517 aa); 11 GOA rows (5 IBA, 5 IEA, 1 IMP from PMID:33408126).
  ZFIN ZDB-GENE-121105-2, Ensembl ENSDARG00000051730, chromosome 25.
• Deep research unavailable: Edison returned 402 Payment Required and the OpenAI key is invalid. Literature
  searched by hand via Europe PMC (see ../slc7a10a/slc7a10a-notes.md for queries).
• DANRE_DUPLICATION batch 4, random draw 18 (seed 20260928); paralog slc7a10a. Pair analysis in
  ../slc7a10a/slc7a10a-bioinformatics/.

Zebrafish literature

• Obesity model: slc7a10b loss of function accelerates diet-induced weight gain
  PMID:33408126.
  The primary paper is cached as abstract only. The same group's review gives details:
  PMID:36172277;
  PMID:36172277;
  PMID:36172277.
  The copy was chosen for sequence identity, not expression; slc7a10a was not studied and paralog compensation was
  not measured.
• Meninges scRNA-seq: SLC7A10B among transporters enriched in arachnoid cells
  PMID:35805100.
• No ZFIN curated expression and no EST profile PMID:34338990.

Mammalian background

See ../slc7a10a/slc7a10a-notes.md.

My analysis

See ../slc7a10a/slc7a10a-bioinformatics/RESULTS.md: protein conserved at all tested Asc-1 residues; slc7a10b is
the slower-evolving copy; expression low and narrow (brain, eye, bone, testis, early embryo), closer to the gar
pattern than slc7a10a.

GOA review decisions

• The 10 IBA/IEA rows accepted, as for slc7a10a.
• Energy homeostasis (IMP, acts upstream of or within) kept as non-core: real, copy-specific phenotype, but an
  organism-level consequence of adipocyte amino acid transport.