Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Activation-induced ubiquitination of the T cell antigen receptor.
Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.
Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3.
Regulatory mechanisms in T cell receptor signalling.
Structural basis of assembly of the human T cell receptor-CD3 complex.
A reference map of the human binary protein interactome.
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.
TCR complex interacts with peptide antigen-presenting MHC Class I
Phosphorylation of ITAM motifs in CD3 complexes
Phosphorylation of ZAP-70 by Lck
Dephosphorylation of Lck-pY505 by CD45
Phosphorylation of SLP-76
Inactivation of Lck by Csk
Phosphorylation of TBSMs in LAT
Phosphorylation of PLC-gamma1
Change of PKC theta conformation
Recruitment of ZAP-70 to phosphorylated ITAMs
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
TCR binds self-lipid-based antigen via CD1
TCR binds microbial lipid-based antigen via CD1
Inactivation of LCK by PTPN22
PTPN22 dephosphorylates ZAP70
AP-2 directly binds some endocytic cargo
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
The structural basis of T-cell receptor (TCR) activation: An enduring enigma.
Structural understanding of T cell receptor triggering.
Structures of human γδ T cell receptor-CD3 complex.
Stoichiometry of the murine gammadelta T cell receptor.
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Hayes and Love leave human gamma-delta TCR composition open and cite reports of CD3 delta-epsilon dimers in human gamma-delta TCRs (fewer than in alpha-beta TCRs on primary cells; comparable on expanded clones, as unpublished data).
"It is not clear, however, whether human γδTCRs share the same bias for CD3γɛ dimers."
Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies.
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Siegers et al. showed that digitonin-isolated primary and cultured human gamma-delta TCRs contain CD3 delta, whereas mouse gamma-delta TCRs do not incorporate CD3 delta.
"The gammadelta TCR isolated in digitonin from primary and cultured human gammadelta T cells includes CD3delta"
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Anti-TCRgammadelta immunopurification from healthy-donor PBMCs recovered CD3 delta in roughly equal amounts to the alpha-beta TCR, resolving an earlier report that primary human gamma-delta TCRs lack CD3 delta (attributed to co-migration of the differently glycosylated CD3 delta with CD3 gamma).
"In conclusion, our data show that the human γδ TCR contains CD3δ in cultured as well as in primary γδ T cells."
Falcon deep research report for human CD3D