Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Reelin is a ligand for lipoprotein receptors.
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.
Integration of endocytosis and signal transduction by lipoprotein receptors.
The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits.
Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk.
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Molecular basis for LDL receptor recognition by PCSK9.
Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor.
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
Defining the membrane proteome of NK cells.
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.
Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids.
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH.
The structure, dynamics, and binding of the LA45 module pair of the low-density lipoprotein receptor suggest an important role for LA4 in ligand release.
Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus.
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.
MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells.
The closed conformation of the LDL receptor is destabilized by the low Ca(++) concentration but favored by the high Mg(++) concentration in the endosome.
Analysis of a recycling-impaired mutant of low density lipoprotein receptor in familial hypercholesterolemia.
Architecture of the human interactome defines protein communities and disease networks.
Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex.
A reference map of the human binary protein interactome.
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA.
The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor.
Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor.
Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.
LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]
LDLR [endosome membrane] => LDLR [plasma membrane]
LDLR:LDL complex => LDLR + LDL
LDL + LDLR => LDL:LDLR complex
LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)
chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex
chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
PCSK9:LDLR bind to Clathrin
Degradation of PCSK9:LDLR:Clathrin-coated vesicle
LDLR is bound by DAB2 and ARH
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2