Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation.
Decoding endocrine cell differentiation: insights from high-throughput CRISPR screening in human gut organoids.
Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue.
NEUROG3-dependent synthesis of PAX4 protein
Complete loss of PAX4 causes transient neonatal diabetes in humans.
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.
PAX4 R192H variant impairs β cell function by disrupting β cell identity and compensatory capacity in response to metabolic stress.
dentification and characterization of novel PAX4 variants in patients with suspected MODY9.
C.487C>T mutation in PAX4 gene causes MODY9: A case report and literature review.
Statistical evidence for high-penetrance MODY-causing genes in a large population-based cohort.
Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
PAX4 mutations in Thais with maturity onset diabetes of the young.
Autoregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter.
Expression of dominant negative form of PAX4 in human insulinoma.
[Alternative Variants of Pax4 Human Transcription Factor: Comparative Transcriptional Activity].
Overexpression of PAX4 reduces glucagon expression in differentiating hESCs.
The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.
Pax4 in Health and Diabetes.
PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet.
Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene.
DNA binding and transactivating properties of the paired and homeobox protein Pax4.
Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.
Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells.
The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.
human/PAX4/PAX4-uniprot.txt
human/PAX4/PAX4-deep-research-claude-code.md
OpenScientist blinded function-assignment report on PAX4 and retina development in camera-type eye (GO:0060041)
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Given only the hypothesis, the GO term and the IBA reference, OpenScientist judged retina development over-annotated for PAX4 and attributed the IBA signal to the PAX6 branch.
"Over-annotated / weakly supported — the term should NOT be retained as a confident PAX4 function."
human/PAX4/PAX4-bioinformatics/RESULTS.md
mouse/Pax4/Pax4-bioinformatics/panther_tree_paths.md