JAR1 (At2g46370; UniProt Q9SKE2) curation notes

2026-10-06 — initial review (jasmonate_coi1_jaz_signaling module)

Fetched with just fetch-gene ARATH JAR1; UniProt record checked: JAR1_ARATH, Q9SKE2, At2g46370, synonym FIN219.
just deep-research-falcon ARATH JAR1 failed (provider rate limit / HTTP 429); no deep-research file. Review based on cached publications.

JAR1 is a GH3 acyl acid-amido synthetase of the ANL adenylating superfamily; adenylation activity specific for JA PMID:12084835.
Forms JA-Ile; jar1 has strongly reduced JA-Ile PMID:15258265; JA-Ile rescues jar1 root inhibition PMID:15258265.
Ile preference PMID:18247047.
Structures: AtGH3.11/JAR1 PMID:22628555; FIN219-FIP1 complex, ordered binding (JA first) and FIP1 doubles adenylation activity PMID:28223489.
Side reaction: p4A synthesis PMID:17291501.

Cytoplasm PMID:10921909. Nuclear ISM prediction and vacuole HDA marked over-annotated.

GO:0018117 protein adenylylation (IDA, PMID:28223489) is a mis-mapping: the assay adenylates JA (PPi release), not a protein -> MODIFY to GO:0009694.
Protein binding (FIP1/GSTU20) -> MODIFY to enzyme binding (already annotated from PMID:17220357).
SAR IEP (PMID:17419843) marked over-annotated (expression only; SAR is SA-dependent).
Negative regulation of defense response (PMID:16732289, mlo paper) left UNDECIDED: abstract-only, states mlo resistance is JA-independent; jar1-specific result not visible.
Many physiological IMPs (ISR, ozone, fumonisin, UV-B, stomata, far-red light) kept as non-core outputs of JA-Ile formation / phyA crosstalk.

GO:0031348 negative regulation of defense response (IMP, PMID:16732289): Europe PMC reports no PMC/open-access full text; WebSearch summaries say mlo2 early senescence is SA- but not JA-dependent, and the JAR1-specific experiment could not be seen. Changed UNDECIDED -> KEEP_AS_NON_CORE, deferring to the GOA curator (CLAUDE.md), as plausible via JA-SA antagonism (cf. jar1 in ozone cell death, PMID:11006337). Non-core, indirect.