Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
The protooncogene TCL1 is an Akt kinase coactivator.
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Crystal structure of an inactive Akt2 kinase domain.
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Kinetic mechanism of AKT/PKB enzyme family.
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.
Akt2 is implicated in skeletal muscle differentiation and specifically binds Prohibitin2/REA.
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
Vimentin is a novel AKT1 target mediating motility and invasion.
Interactions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes.
Akt1 and Akt2: differentiating the aktion.
Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2).
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2.
MicroRNA-29s could target AKT2 to inhibit gastric cancer cells invasion ability.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PDPK1 phosphorylates AKT2
Phosphorylation of TSC2 by AKT (PKB)
Phosphorylation of complexed TSC2 by PKB
Activated Akt1 phosphorylates AKT1S1 (PRAS40)