SLC1 (YDL052C, P33333) notes

Evidence journal compiled from the UniProt record and cached publications (no paid deep research).

Activity

• sn-2 acyl-CoA:LPA acyltransferase (LPAAT, EC 2.3.1.51) PMID:17675291
• In slc1 lipid particles acylation stops at LPA PMID:9401016
• SLC1-1 variant acylates sn-1 oleoyl-LPA in vitro PMID:9212466
• Broad lysophospholipid acceptor range in microsomes (LPA, LPC, LPE, LPS, LPI) and reversibility on PA PMID:26643989; PMID:17675291
• Redundancy: slc1 ale1(slc4) double deletion lethal PMID:17675291

Location

• ER and lipid droplets PMID:24868093
• UniProt: Lipid droplet [UniProt:P33333]

Curation observations

• YeastPathways RCA rows place LPAAT activity in "cytosol" (pathway default) -> MODIFY to ER membrane.
• TAG biosynthesis and CDP-DAG biosynthesis are downstream uses of PA; kept as non-core.
• Lyso-PC/PE/PS acyltransferase activities are real in vitro but secondary (Ale1 is the main remodelling enzyme).