Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation based on rule-based mapping of RHEA reactions to GO molecular functions
Combined Automated Annotation using Multiple IEA Methods
Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.
MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.
Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest.
Effect of C-terminal truncations on MLK7 catalytic activity and JNK activation.
The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.
Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.
Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Towards a proteome-scale map of the human protein-protein interaction network.
ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.
ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells.
Next-generation sequencing to generate interactome datasets.
Toward an understanding of the protein interaction network of the human liver.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.
Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains.
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate.
-
ZAKalpha senses ribosome collisions and, depending on severity, activates the stress-activated p38/JNK cascade (cell death) or EIF2AK4/GCN2-mediated integrated stress response (survival); it preferentially associates with colliding ribosomes.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
A central chaperone-like role for 14-3-3 proteins in human cells.