Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.
Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.
Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo.
Functional proteomics mapping of a human signaling pathway.
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation.
Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells.
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.
NOM1 targets protein phosphatase I to the nucleolus.
A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells.
Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155).
Docking motif-guided mapping of the interactome of protein phosphatase-1.
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Identification and characterization of a novel human PP1 phosphatase complex.
Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators.
RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.
Flexibility in the PP1:spinophilin holoenzyme.
Identification of the human testis protein phosphatase 1 interactome.
Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.
Proteomic characterization of the human sperm nucleus.
Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.
Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
Protein phosphatase 1α interacting proteins in the human brain.
Dynamic protein-protein interaction wiring of the human spliceosome.
Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.
The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.
Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.
A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
A proteome-scale map of the human interactome network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.
Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.
Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Quantitative interaction proteomics of neurodegenerative disease proteins.
ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.
Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Architecture of the human interactome defines protein communities and disease networks.
Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.
Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation.
KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.
PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.
Effects of stably incorporated iron on protein phosphatase-1 structure and activity.
Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a "Sitting Duck Torpedo" Mechanism.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.
Structural basis for SHOC2 modulation of RAS signalling.
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.
Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis.
CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation.
The PNUTS phosphatase complex controls transcription pause release.
The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.
Multimodal cell maps as a foundation for structural and functional genomics.
Cloning and characterization of a human protein phosphatase 1-encoding cDNA.
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function
P:PP1 dephosphorylates M2-1
Recruitment of other CPA components to pre-mRNA-bound CPA core
PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS
PP1 dephosphorylates RNA Pol II
RBBP6 activates CPSF complex
CPSF3 cleaves pre-mRNA at distal 3'UTR PAS
U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS
CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS
PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS
PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS
CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)
CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)
CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)