Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

Widespread macromolecular interaction perturbations in human genetic disorders.

Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy.

A reference map of the human binary protein interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver.

UniProt entry P43897 (EFTS_HUMAN)

Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs.

Mutation in the mitochondrial translation elongation factor EFTs results in severe infantile liver failure.

Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.

Novel compound mutations in the mitochondrial translation elongation factor (TSFM) gene cause severe cardiomyopathy with myocardial fibro-adipose replacement.