GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

Phylogenetic inference of ELOVL family functions including fatty acid elongase activity, ER membrane localization, and involvement in fatty acid elongation processes.

GO_REF:0000043

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10970790

Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.

Original cloning and characterization of ELOVL5 (then called HELO1)
Demonstrated elongation of gamma-linolenic acid, alpha-linolenic acid, stearidonic acid, arachidonic acid, and EPA
Showed highest expression in adrenal gland and testis
Localized gene to chromosome 6

PMID:19946888

Defining the membrane proteome of NK cells.

Proteomics identification of ELOVL5 as membrane protein

PMID:20427700

Validation of the health ABC heart failure model for incident heart failure risk prediction - The Cardiovascular Health Study.

PMID:20937905

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

Systematic in vitro characterization of all ELOVL substrate specificities
Demonstrated ELOVL5 preference for PUFA substrates
Showed ELOVL1 (not ELOVL5) is responsible for C24 sphingolipid synthesis
Confirmed ER membrane localization

PMID:23749231

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.

siELOVL5 knockdown reduced de novo lipogenesis
ELOVL5 is a target of miR-30c regulation
Demonstrated role in hepatic lipid synthesis

PMID:25065913

ELOVL5 mutations cause spinocerebellar ataxia 38.

Identified ELOVL5 mutations as cause of SCA38
Showed reduced arachidonic acid and DHA in patient serum
Demonstrated high expression in Purkinje cells (soma and dendrites)
Wild-type localizes to ER; mutants show abnormal Golgi accumulation

PMID:32296183

A reference map of the human binary protein interactome.

High-throughput identification of ELOVL5 protein interactions

PMID:38422897

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation.

Demonstrated ELOVL5 interaction with TECR
Supports model of coordinated elongation cycle enzyme complex

Reactome:R-HSA-2046083

Elongation of arachidonyl-CoA to docosatetraenoyl-CoA

ELOVL5 catalyzes this specific elongation reaction

Reactome:R-HSA-2046088

Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA

ELOVL5 involved in n-3 PUFA pathway

Reactome:R-HSA-2046094

Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA

Key step in n-6 PUFA pathway (GLA to DGLA)

Reactome:R-HSA-2046100

Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA

ELOVL5 elongates EPA toward DHA synthesis

Reactome:R-HSA-2046105

Linoleic acid (LA) metabolism

ELOVL5 functions in n-6 PUFA synthesis pathway from dietary linoleic acid

Reactome:R-HSA-2046106

alpha-linolenic acid (ALA) metabolism

ELOVL5 functions in n-3 PUFA synthesis pathway from dietary ALA

Reactome:R-HSA-548800

ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA

ELOVL5 contributes to arachidonate elongation

Reactome:R-HSA-75876

Synthesis of very long-chain fatty acyl-CoAs

ELOVL5 is one of seven ELOVL elongases in the VLCFA synthesis pathway

file:human/ELOVL5/ELOVL5-deep-research-falcon.md

Deep research report on ELOVL5