Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10679095

Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL.

Tagged human SART2/DSE localizes predominantly to the ER with a Golgi-associated pool; a vesicle pattern observed in COS7 cells is absent in the MCF-7 comparison.

PMID:16505484

Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.

Human DSE directly epimerizes glucuronic acid in chondroitin, increasing iduronic acid and iduronate-rich regions in cellular CS/DS chains.

PMID:19004833

Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function.

Human tagged-enzyme mutagenesis and glycosylation experiments support epimerase function, while the proposed atomic mechanism remains distinct from the measured net reaction.

PMID:7092807

Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase.

Human-fibroblast microsomal activity supports C5 epimerization on chondroitin and differs from the heparan-substrate epimerase system.

Reactome:R-HSA-2022052

DSE converts GlcA to IdoA

Reactome:R-HSA-2022923

DS-GAG biosynthesis

PMID:33815739

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.

The human catalytic-domain structure identifies a metal-binding environment and supports a revised catalytic model for the established epimerization reaction.

PMID:22496542

Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition.

Mouse Dsel loss changes brain CS/DS iduronic-acid content and sulfation, providing paralog-specific experimental support for the conserved chain-modification role.