UniProtKB entry Q9BXW9 (FACD2_HUMAN), Fanconi anemia group D2 protein
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Menin associates with FANCD2, a protein involved in repair of DNA damage.
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3.
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair.
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
DNA polymerase POLN participates in cross-link repair and homologous recombination.
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.
FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress.
The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex
Monoubiquitination of FANCD2:FANCI
DNA nucleases bind monoubiquitinated ID2 complex
DNA nucleases unhook the interstrand crosslink (ICL)
Translesion synthesis across unhooked ICL by POLN
FANCD2 deubiquitination by USP1:WDR48
The complex of ATR and ATRIP is recruited to ICL-DNA
ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA
CDK12 stimulates expression of DNA repair genes