Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Dysferlin is a plasma membrane protein and is expressed early in human development.

Dysferlin is a surface membrane-associated protein that is absent in Miyoshi myopathy.

Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains.

AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Reduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathway.

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repair.

Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.

Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins.

DYSF, CAV3 and TRIM72 bind

Quantitation of the calcium and membrane binding properties of the C2 domains of dysferlin.

From T-tubule to sarcolemma: damage-induced dysferlin translocation in early myogenesis.

Dysferlin is expressed in human placenta but does not associate with caveolin.

The sarcolemmal proteins dysferlin and caveolin-3 interact in skeletal muscle.

Defective membrane repair in dysferlin-deficient muscular dystrophy.

Identification and characterization of a novel human dysferlin transcript: dysferlin_v1.

Identification and characterisation of human dysferlin transcript variants: implications for dysferlin mutational screening and isoforms.

Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stress.

MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity.

DYSF source-audit results

DYSF source and evidence guide

UniProtKB O75923 dysferlin record

Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion.

Dysferlin Binds SNAREs (Soluble N-Ethylmaleimide-sensitive Factor (NSF) Attachment Protein Receptors) and Stimulates Membrane Fusion in a Calcium-sensitive Manner.

DYSF membrane-repair participation and titin-specificity audit