Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
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Human squalene synthase catalyses biosynthesis of squalene through reductive dimerization of two FPP molecules; conversion of FPP to squalene is the first committed step in cholesterol formation.
"through a reductive dimerization of two farnesyl diphosphate (FPP)"
The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.
Widespread macromolecular interaction perturbations in human genetic disorders.
A reference map of the human binary protein interactome.
Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.
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Squalene synthetase (EC 2.5.1.21) is a major control point of isoprene and sterol biosynthesis; the human enzyme is a C-terminal membrane-spanning ~50 kDa protein and functionally complements sterol-deficient (ERG9) yeast.
"is thought to represent a major control point"
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
Reduction of presqualene diphosphate to form squalene
Two FAPP molecules dimerize to form presqualene diphosphate
UniProtKB P37268 (FDFT_HUMAN) entry - Squalene synthase